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Related Experiment Video

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Three-Dimensional Dosimetry for Radiation Safety Estimates from Intrathecal Administration.

Jacob Y Hesterman1, Susan D Kost2, Robert W Holt3

  • 1inviCRO, Boston, Massachusetts hesterman@invicro.com.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|March 25, 2017
PubMed
Summary

This study adapted dosimetry software for intrathecal administration, revealing radiation doses are concentrated in cerebrospinal fluid (CSF) and spinal regions. Findings support tailored radiation safety assessments for intrathecal imaging and drug delivery studies.

Keywords:
dosimetryintrathecal administrationradiation safety

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Area of Science:

  • Medical Imaging and Dosimetry
  • Radiopharmaceutical Therapy and Nuclear Medicine

Background:

  • Intrathecal administration is gaining traction for drug delivery, necessitating precise radiation safety evaluations.
  • Current dosimetry tools require adaptation for the unique anatomical and physiological considerations of intrathecal delivery.

Purpose of the Study:

  • To extend the 3-dimensional Voxel-Based Internal Dosimetry Application (VIDA) and 4D Extended Cardiac Torso Phantom (XCAT) for intrathecal administration.
  • To provide specific radiation safety estimates for intrathecal drug delivery and imaging studies.

Main Methods:

  • A modified XCAT phantom was used with Monte Carlo simulations in VIDA to generate voxel-level absorbed dose maps.
  • Simulation results were validated against the OLINDA/EXM dosimetry tool.
  • Absorbed dose was estimated in 6 healthy subjects receiving 99mTc-diethylenetriaminepentaacetic acid via intrathecal administration.

Main Results:

  • Simulation estimates closely aligned with OLINDA/EXM for common organs (within 6%).
  • Highest absorbed doses were observed in the lumbar cerebrospinal fluid (CSF) space (0.3-0.8 mGy/MBq).
  • A whole-body effective dose of 0.003 mSv/MBq was calculated, with lower doses noted for larger administered volumes (15 mL).

Conclusions:

  • The adapted VIDA implementation offers tailored dosimetry for intrathecal administration.
  • Radiation exposure is primarily localized to CSF and spinal regions.
  • The relationship between administered volume and absorbed dose warrants further investigation for optimizing intrathecal therapies.