Related Experiment Video
Updated: Mar 5, 2026
04:37
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
807
Hyperbaric oxygen therapy reduces renal lactate production.
Thomas S Nørlinger1, Per Mose Nielsen1, Haiyun Qi1
1Department of Clinical Medicine, MR Research Centre, Aarhus University, Aarhus, Denmark.
Physiological Reports
|March 25, 2017
Summary
Hyperbaric oxygen therapy reduces intrarenal lactate production in diabetic rats, as shown by novel hyperpolarized [1-13C]pyruvate MRI. This technique monitors metabolic changes during hyperbaric oxygen (HBO) treatment.
Area of Science:
- Nephrology
- Biochemistry
- Medical Imaging
Background:
- Diabetic nephropathy is linked to intrarenal hypoxia.
- Hyperbaric oxygen (HBO) therapy is an established treatment, but its metabolic effects are unclear.
- Investigating HBO's impact on kidney metabolism in diabetes is crucial.
Purpose of the Study:
- To examine the effects of HBO on intrarenal metabolic alterations in a rat model of diabetes.
- To evaluate hyperpolarized [1-13C]pyruvate MRI as a method to monitor these metabolic changes.
Main Methods:
- Streptozotocin-induced diabetic and normoglycemic control rats were used.
- Hyperpolarized [1-13C]pyruvate Magnetic Resonance Imaging (MRI) assessed kidney energy metabolism.
- Rats received five days of HBO therapy.
Main Results:
- HBO therapy significantly reduced intrarenal lactate production in both diabetic and control rats.
- This reduction was observed three days post-therapy.
- Lactate dehydrogenase mRNA expression and activity remained unaffected by HBO.
Conclusions:
- Hyperbaric oxygen therapy can alter intrarenal metabolism by reducing lactate production.
- Hyperpolarized [1-13C]pyruvate MRI is a promising tool for monitoring HBO therapy effectiveness.
- This MRI technique visualizes pyruvate-to-lactate conversion, reflecting metabolic response to HBO.
Related Concept Videos
01:16Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
691
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
691
01:27Oxygen Transport in the Blood
7.6K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
7.6K
01:18Respiratory Regulation of Acid-Base Balance
2.0K
Respiratory compensation is a vital physiological process that stabilizes blood plasma pH by regulating the partial pressure of carbon dioxide (PCO2), a key determinant of pH levels. Most carbon dioxide in the blood dissolves and converts into carbonic acid (H2CO3). It dissociates into hydrogen ions (H+) and bicarbonate ions (HCO3⁻). There is also an inverse relationship between PCO2 and pH.
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
2.0K
01:24Muscle Recovery and Fatigue
4.6K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.6K
02:23Alcohols from Carbonyl Compounds: Reduction
12.8K
Reduction is a simple strategy to convert a carbonyl group to a hydroxyl group. The three major pathways to reduce carbonyls to alcohols are catalytic hydrogenation, hydride reduction, and borane reduction.
Catalytic hydrogenation is similar to the reduction of an alkene or alkyne by adding H2 across the pi bond in the presence of transition metal catalysts like Raney Ni, Pd–C, Pt, or Ru. Aldehydes and ketones can be reduced by this method, often under mild to moderate heat (25–100°C) and...
Catalytic hydrogenation is similar to the reduction of an alkene or alkyne by adding H2 across the pi bond in the presence of transition metal catalysts like Raney Ni, Pd–C, Pt, or Ru. Aldehydes and ketones can be reduced by this method, often under mild to moderate heat (25–100°C) and...
12.8K
01:29Renal Regulation of Acid-Base Balance
2.1K
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
2.1K