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Fgf21 regulates T-cell development in the neonatal and juvenile thymus

Yoshiaki Nakayama1, Yuki Masuda1, Hiroya Ohta1,2

  • 1Department of Microbial Chemistry, Kobe Pharmaceutical University, Kobe, Japan.

Scientific Reports
|March 25, 2017
PubMed
Summary

Fibroblast growth factor 21 (FGF21) plays a crucial role in juvenile thymus development. FGF21 enhances T cell selection by promoting apoptosis of immature thymocytes, acting independently of β-Klotho.

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