Related Experiment Video

Updated: Mar 5, 2026

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients
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Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients

Published on: October 16, 2016

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Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing

Danna Chen1,2, Dongdong Liu2, Dan Liu2

  • 1Department of Laboratory Science, Zengcheng District People's Hospital of Guangzhou (BoJi-Affiliated Hospital of Sun Yat-sen University), Guangzhou, 511300, China.

Scientific Reports
|March 25, 2017
PubMed

Insights

This study reveals that PTEN suppresses survivin, a key protein in rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLS). This finding suggests PTEN-based therapies could be a novel treatment for RA joint damage.

Area of Science:

  • Molecular Biology
  • Immunology
  • Rheumatology

Background:

  • Survivin, a proto-oncogene, promotes cell survival and proliferation via the PI3K/Akt pathway.
  • In rheumatoid arthritis (RA), elevated survivin correlates with severe joint damage and poor treatment outcomes.
  • The role of PTEN, a PI3K antagonist, in regulating survivin in RA remains unclear.

Purpose of the Study:

  • To investigate the effect of PTEN on survivin gene expression in RA fibroblast-like synoviocytes (RA-FLS).
  • To elucidate the interplay between PTEN and survivin in the context of RA pathogenesis.

Main Methods:

  • Primary RA-FLS were utilized to examine PTEN's influence on survivin expression.
  • Gene expression analysis was performed to quantify survivin levels following PTEN modulation.

Main Results:

  • PTEN was found to suppress survivin gene expression in RA-FLS.
  • This suppression by PTEN was identified as the mechanism mediating the inhibition of RA-FLS proliferation.
  • The study demonstrated PTEN-mediated survivin silencing in RA-FLS for the first time.

Conclusions:

  • PTEN plays a critical role in regulating survivin expression in RA pathogenesis.
  • Targeting PTEN could represent a novel therapeutic strategy for managing rheumatoid arthritis.
  • Survivin suppressants, potentially acting through PTEN, may offer new treatment avenues for RA patients.

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