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Comparative physical dependence studies in rats with flupirtine and opiate receptor stimulating analgesics
1Biological Research Pharmacology, Homburg Degussa Pharma Gruppe, Frankfurt, Federal Republic of Germany.
Postgraduate Medical Journal
|January 1, 1987
Abstract:
In physical dependence studies in rats the principle criterion was loss of body weight after withdrawal of the dependence producing drug. Other typical signs of withdrawal were also observed. In contrast to buprenorphine, codeine and tramadol, flupirtine caused no decrease in body weight and no other withdrawal symptoms. Flupirtine does not produce opiate type physical dependence.