Related Experiment Video
Updated: Mar 5, 2026
09:28
Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles
Published on: November 17, 2018
12.1K
MAGE-A Antigens and Cancer Immunotherapy
Paul Zajac1, Elke Schultz-Thater1, Luigi Tornillo2
1Oncology Surgery, Department of Biomedicine, University Hospital of Basel , Basel , Switzerland.
Frontiers in Medicine
|March 25, 2017
Summary
Melanoma-associated antigen (MAGE-A) specific immunotherapies show promise for treating various cancers due to tumor specificity. This review analyzes current MAGE-A clinical trials and discusses future improvements for cancer treatment.
Area of Science:
- Oncology
- Immunology
- Cancer Research
Background:
- Melanoma-associated antigen (MAGE-A) proteins are expressed in various cancers and germ cells.
- MAGE-A antigens exhibit high tumor specificity, making them ideal targets for cancer immunotherapy.
- Current immunotherapies leverage MAGE-A antigens for targeted cancer treatment.
Purpose of the Study:
- To review existing and ongoing clinical studies focused on MAGE-A antigen-targeted immunotherapies.
- To critically analyze the benefits and drawbacks of different therapeutic strategies.
- To explore potential advancements for enhancing MAGE-A-specific cancer immunotherapies.
Main Methods:
- Comprehensive literature review of clinical studies.
- Analysis of therapeutic approaches targeting MAGE-A antigens.
- Discussion of future directions in MAGE-A immunotherapy.
Main Results:
- MAGE-A antigens are validated targets in diverse cancers.
- Various active specific and adoptive immunotherapy approaches are under investigation.
- Clinical efficacy and safety profiles vary across different MAGE-A-targeting strategies.
Conclusions:
- MAGE-A-specific immunotherapies offer a promising avenue for cancer treatment.
- Further research is needed to optimize therapeutic strategies and overcome challenges.
- Advancements in MAGE-A immunotherapy hold potential for improved patient outcomes in oncology.
More Related Videos
11:02Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
21.8K
09:56A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
1.5K
Related Concept Videos
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
01:26Antigens Involved in Adaptive Immunity
1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
02:38Mitogens and the Cell Cycle
8.2K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.2K
01:30Cancer Vaccines
1.2K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.2K
02:43Mouse Models of Cancer Study
6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
03:03mTOR Signaling and Cancer Progression
5.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
5.0K