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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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Intelligent Informatics in Translational Medicine 2016

Hao-Teng Chang1, Tatsuya Akutsu2, Oliver Ray3

  • 1Graduate Institute of Basic Medical Science, College of Medicine, China Medical University, Taichung, Taiwan; Department of Computer Science and Information Engineering, Asia University, Taichung, Taiwan; Department of Science Education, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.

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