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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Oral Drug Delivery Systems: Delayed-Release Systems01:11

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Related Experiment Video

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Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
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Self-assembled polyelectrolyte complexes films as efficient compression coating layers for controlled-releasing

Wenyan Li1, Mengmeng Huo1, Arka Sen Chaudhuri1

  • 1Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.

Journal of Materials Science. Materials in Medicine
|March 25, 2017
PubMed
Summary
This summary is machine-generated.

Chitosan (CS) and sodium alginate (SA) polyelectrolyte complex (PEC) films were used to create controlled-release tablets. These novel drug delivery systems demonstrated prolonged drug release and improved pharmacokinetic profiles for paracetamol (APAP).

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biomedical Engineering

Background:

  • Polysaccharide-based hydrogels are explored for modifying drug dissolution in controlled-release matrix tablets.
  • Polyelectrolyte complexes (PEC) films from chitosan (CS) and sodium alginate (SA) self-assemble in gastrointestinal environments.
  • PEC films offer potential as coating materials for advanced drug delivery systems.

Purpose of the Study:

  • To develop controlled-release matrix tablets using self-assembled PEC films as coating materials.
  • To evaluate the efficacy of CS/SA PEC films in a compression coating process for paracetamol (APAP) delivery.
  • To assess the in vitro and in vivo performance of the developed controlled-release tablets.

Main Methods:

  • Fabrication of polyelectrolyte complex (PEC) films using chitosan (CS) and sodium alginate (SA) at a 1:1 weight ratio.
  • Development of controlled-release matrix tablets via compression coating with PEC films.
  • Characterization of PEC film properties and morphology.
  • In vitro drug release studies of paracetamol (APAP) from coated tablets.
  • In vivo pharmacokinetic evaluation in New Zealand rabbits comparing coated tablets to a commercial formulation.

Main Results:

  • The CS/SA PEC films with a 1:1 weight ratio showed promising characteristics for compression coating.
  • Optimized compression-coated tablets exhibited satisfactory zero-order drug release kinetics.
  • In vivo studies demonstrated a significant prolongation of Tmax for APAP from the coated tablets (12.32 ± 1.05 h) compared to conventional tablets (0.89 ± 0.26 h).

Conclusions:

  • Self-assembled CS/SA PEC films are effective coating materials for developing peroral controlled-release drug delivery systems.
  • Compression-coated tablets utilizing PEC films represent a viable strategy for enhancing the pharmacokinetic profiles of water-soluble drugs.
  • This approach offers a promising avenue for improving the efficacy and patient compliance of controlled-release medications.