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Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
Quality control of apheresis platelets: a multicentre study to evaluate factors that can influence pH measurement
M Germain1, Y Grégoire1, R R Vassallo2
1Héma-Québec, Quebec, QC, Canada.
Background And Objectives:
Blood operators routinely monitor the pH of apheresis platelets as a marker of the so-called storage lesion, which can result from manufacturing problems. It is also suspected that some donor characteristics can increase the risk of poor platelet storage. To explore this hypothesis, we analysed a large, multinational data set of quality control (QC) pH test results on apheresis platelets.
Materials And Methods:
For the period between September 2011 and August 2014, seven blood operators in Canada, the USA, the Netherlands, the United Kingdom, France and Australia provided pH QC test results and donor characteristics on a total of 21,671 apheresis platelets.
Results:
Some variations in pH distribution between blood operators were in part explained by differences in collection, processing and testing methods. Younger age and female gender were significantly associated with a pH value below the 10th percentile. Among donors who had two or more pH measurements (n = 3672), there was a strong correlation between pH results (r = 0·726; P < 0·0001).
Conclusion:
The strong intradonor correlation of pH measurements and the association between donor characteristics and pH results suggest that donor factors play a role in the quality of platelets.
