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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
72

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Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
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Transdermal Protein Delivery Using Choline and Geranate (CAGE) Deep Eutectic Solvent.

Amrita Banerjee1, Kelly Ibsen1, Yasunori Iwao2

  • 1Department of Chemical Engineering and Center for Bioengineering, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.

Advanced Healthcare Materials
|March 25, 2017
PubMed
Summary

Choline and geranate (CAGE), a novel deep eutectic solvent, effectively enhances transdermal protein delivery. This breakthrough offers a potential noninvasive alternative to injections for therapeutic proteins like insulin.

Keywords:
choline and geranatedeep eutectic solventinsulinionic liquidstransdermal delivery

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Area of Science:

  • Biomaterials Science
  • Drug Delivery
  • Dermatology

Background:

  • Skin's low permeability impedes transdermal delivery of large molecules like proteins.
  • Existing delivery methods often involve invasive procedures such as injections.

Purpose of the Study:

  • To evaluate choline and geranate (CAGE) as a vehicle for enhancing topical protein delivery.
  • To assess the safety and efficacy of CAGE for transdermal protein permeation and therapeutic effect.

Main Methods:

  • Ex vivo permeation studies using porcine skin with model proteins (BSA, OVA, insulin).
  • In vivo studies in rats to evaluate blood glucose reduction after topical insulin application.
  • Fourier transform IR spectroscopy and circular dichroism to analyze skin structure and protein conformation.

Main Results:

  • CAGE significantly enhanced the permeation of BSA, OVA, and insulin into and across porcine skin.
  • CAGE demonstrated lipid extraction from the stratum corneum without altering insulin's secondary structure.
  • Topical insulin in CAGE reduced blood glucose levels by 40% in rats within 4 hours.

Conclusions:

  • CAGE is a promising deep eutectic solvent for transdermal delivery of therapeutic proteins.
  • This approach presents a viable noninvasive alternative to injectable insulin for diabetes management.