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Related Concept Videos

Three Developmental Domains01:29

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Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
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Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
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Tridimensional Visualization and Analysis of Early Human Development.

Morgane Belle1, David Godefroy1, Gérard Couly1

  • 1Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, 75012 Paris, France.

Cell
|March 25, 2017
PubMed
Summary
This summary is machine-generated.

Researchers created a 3D cellular map of early human development, revealing skin nerve patterns and distinct genital tract vascularization before the first trimester. This atlas aids understanding of human development and disease.

Keywords:
3DISCOdatabaseembryofetushumaniDISCOlight sheet microscopynervous systemtissue clearingurogenital system

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Area of Science:

  • Developmental Biology
  • Human Embryology
  • Cellular Imaging

Background:

  • Precise cellular and molecular cartography of human embryos is crucial for understanding organogenesis.
  • Knowledge gaps exist in early human development, particularly during the first trimester.

Purpose of the Study:

  • To construct a 3D cellular map of human development during the first trimester.
  • To visualize developing organ systems at high resolution.

Main Methods:

  • Whole-mount immunostaining
  • 3DISCO tissue clearing
  • Light-sheet fluorescence microscopy

Main Results:

  • High-resolution 3D images of developing peripheral nervous, muscular, vascular, cardiopulmonary, and urogenital systems.
  • Establishment of adult-like skin innervation patterns before the end of the first trimester, with notable variations.
  • Differential vascularization of male and female genital tracts coinciding with sex determination.

Conclusions:

  • The study provides a foundational 3D cellular atlas for human development.
  • This resource is vital for understanding human development in both health and disease.
  • The findings highlight early establishment of complex anatomical patterns and variations.