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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Updated: Feb 17, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
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Pediatric Microsurgery: A Global Overview.

Ali Izadpanah1, Steven L Moran2

  • 1Department of Orthopedic Surgery, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.

Clinics in Plastic Surgery
|March 26, 2017
PubMed
Summary
This summary is machine-generated.

Free tissue transfer is a reliable microsurgical technique for pediatric reconstruction of soft tissue and bony defects. This single-stage approach offers advantages over traditional methods for children.

Keywords:
ChildrenFree tissue transferMicrosurgeryPediatric

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Area of Science:

  • Plastic Surgery
  • Pediatric Surgery
  • Microsurgery

Background:

  • Microsurgical expertise has advanced, enabling the use of smaller, more refined flaps.
  • Free tissue transfer has become increasingly popular for pediatric reconstructive surgery.
  • Pediatric microsurgery has proven technically feasible and reliable over the last 20 years.

Purpose of the Study:

  • To review the current advancements and applications of pediatric microsurgery.
  • To highlight the benefits of free tissue transfer in managing pediatric defects.

Main Methods:

  • Review of current literature on pediatric microsurgery.
  • Analysis of the application of free tissue transfer in pediatric cases.

Main Results:

  • Free tissue transfer is a viable and effective method for pediatric reconstruction.
  • This technique allows for single-stage defect management.

Conclusions:

  • Free tissue transfer represents the state-of-the-art in pediatric microsurgery.
  • It offers a superior alternative to historical treatments like skin grafting and tissue expansion for pediatric defects.