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Serum vitamin D level in Egyptian children with Familial Mediterranean fever

Hala M Lotfy1, Huda Marzouk1, Yomna Farag1

  • 1Department of Pediatrics, Cairo University, Egypt.

Immunology Letters
|March 26, 2017
PubMed

Insights

Egyptian children with Familial Mediterranean Fever (FMF) have lower vitamin D levels than healthy children. This suggests vitamin D deficiency may be linked to FMF inflammation, warranting further research and potential supplementation.

Area of Science:

  • Pediatrics
  • Immunology
  • Endocrinology

Background:

  • Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disorder.
  • Vitamin D plays a crucial role in immune system regulation.
  • Low vitamin D levels have been observed in various inflammatory conditions.

Purpose of the Study:

  • To compare plasma vitamin D levels in Egyptian children diagnosed with FMF against a control group of healthy children.
  • To investigate potential correlations between vitamin D status and clinical, laboratory, or genetic factors in pediatric FMF patients.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was utilized to quantify serum vitamin D levels.
  • The study included 52 Egyptian children with FMF and 40 healthy controls.
  • Demographic and clinical data were collected for all participants.

Main Results:

  • Children with FMF exhibited significantly lower mean serum vitamin D levels (12.3±3.4 ng/mL) compared to healthy controls (21.2±3.5 ng/mL) (p<0.001).
  • Female FMF patients presented with lower vitamin D levels (11.3±2.9 ng/mL) than male patients (13.2±3.6 ng/mL) (p=0.04).
  • No significant associations were found between vitamin D levels and clinical, laboratory, or genetic variables in the FMF cohort.

Conclusions:

  • Egyptian children with FMF demonstrate lower vitamin D levels than their healthy peers.
  • Vitamin D deficiency in FMF may be associated with the underlying inflammatory processes.
  • Further research, including therapeutic trials, is recommended to explore vitamin D supplementation for FMF patients.
Abstract

Keywords:
ChildrenEgyptian childrenFamilial Mediterranean feverPlasma vitamin D

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