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Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

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Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
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Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Lipid Catabolism01:25

Lipid Catabolism

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Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
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Related Experiment Video

Updated: Mar 5, 2026

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
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Lipidomics: Prospects from a technological perspective.

Alexander Triebl1, Jürgen Hartler2, Martin Trötzmüller1

  • 1Center for Medical Research (ZMF), Medical University of Graz, Stiftingtalstrasse 24, 8010 Graz, Austria.

Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids
|March 26, 2017
PubMed
Summary
This summary is machine-generated.

Lipidomics, a field advancing with mass spectrometry, offers a comprehensive overview of its workflow, challenges, and future directions. This technology provides insights comparable to genomics and proteomics.

Keywords:
Biomarker discoveryChromatographyData processingLipid extractionLipidomicsMass spectrometry

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Area of Science:

  • Biochemistry
  • Analytical Chemistry

Background:

  • Lipidomics has emerged as a key 'omics' technology over the past 20 years.
  • Advancements in mass spectrometry have been the primary driver of lipidomics development.

Purpose of the Study:

  • To provide a comprehensive overview of the technological state of the art in lipidomics.
  • To discuss current challenges and future perspectives in the field of lipidomics.
  • To guide readers through the entire lipidomics workflow, from sampling to data analysis.

Main Methods:

  • Review of technological advancements in mass spectrometry relevant to lipidomics.
  • Analysis of the complete lipidomics workflow, including sample preparation and data analysis.
  • Synthesis of current challenges and future trends in lipidomics research.

Main Results:

  • Lipidomics is now a well-established 'omics' field, comparable to genomics and proteomics.
  • Continuous improvements in mass spectrometry have enabled significant progress in lipidomics.
  • The field faces challenges but holds substantial promise for future development.

Conclusions:

  • Lipidomics is a rapidly evolving field with significant technological advancements.
  • Understanding the lipidomics workflow is crucial for addressing current challenges and realizing future potential.
  • The integration of lipidomics with other 'omics' technologies offers exciting prospects for biological research.