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The High Prevalence of Vitamin D Insufficiency in Cord Blood in Calgary, Alberta (APrON-D Study)

Fariba Aghajafari1, Catherine J Field2, Bonnie J Kaplan3

  • 1Departments of Family Medicine and Community Health Sciences, University of Calgary, Calgary, AB.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|March 26, 2017
PubMed

Insights

High-dose vitamin D supplementation during pregnancy significantly increased vitamin D levels in both mothers and newborns. This finding highlights the importance of adequate vitamin D for a healthy pregnancy and fetal development.

Area of Science:

  • Obstetrics and Gynecology
  • Nutritional Science
  • Pediatrics

Background:

  • Vitamin D plays a crucial role in maternal and fetal health.
  • Maintaining adequate vitamin D levels is essential during pregnancy.
  • Vitamin D insufficiency is a growing concern globally.

Purpose of the Study:

  • To measure 25-hydroxyvitamin D levels in maternal and cord blood.
  • To identify maternal factors associated with vitamin D status.
  • To assess the prevalence of vitamin D insufficiency in pregnant women and neonates in Calgary.

Main Methods:

  • Analysis of maternal and cord blood samples from the ApronStudy.ca cohort.
  • Quantification of 25(OH)D3 using liquid chromatography-mass spectrometry.
  • Statistical analysis to identify factors associated with vitamin D sufficiency.

Main Results:

  • 38% of women and 80% of neonates exhibited vitamin D insufficiency (25(OH)D3 <75 nmol/L).
  • Vitamin D supplementation was the sole clinical factor linked to vitamin D sufficiency.
  • Supplementation exceeding 2000 IU/day increased the odds of sufficiency by 3.75 in women and 5.27 in neonates.

Conclusions:

  • A high prevalence of vitamin D insufficiency was observed in cord blood.
  • High-dose vitamin D supplementation is associated with improved vitamin D status in pregnant women and newborns.
  • Findings underscore the importance of adequate vitamin D intake during pregnancy for optimal maternal and infant outcomes.
Abstract

Keywords:
25(OH)DVitamin Dcord bloodliquid chromatography mass spectrometrypregnancy

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