Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structures of the Endocrine System00:59

Structures of the Endocrine System

14.5K
The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
14.5K
Endocrine Signaling01:45

Endocrine Signaling

68.6K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
68.6K
The Endocrine System01:29

The Endocrine System

1.6K
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
1.6K
What is the Endocrine System?00:46

What is the Endocrine System?

424.7K
The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
424.7K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

3.7K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.7K
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

16.9K
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
16.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal changes in cortisol secretion and their association with long-term outcomes in benign adrenal incidentalomas: a retrospective cohort study.

The lancet. Diabetes & endocrinology·2026
Same author

Living with Legacy: Outcomes and Future Implications for Offspring of Patients with MEN1.

Journal of the ASEAN Federation of Endocrine Societies·2026
Same author

Metastatic neuroendocrine lesions in diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH): a narrative review and case series.

Endocrine oncology (Bristol, England)·2026
Same author

Is preoperative adrenoceptor blockade necessary in patients with paraganglioma?

Endocrine-related cancer·2026
Same author

Shifts in waist-to-height ratio categories within tirzepatide groups: a post-hoc analysis of SURMOUNT-1.

Journal of endocrinological investigation·2026
Same author

Indirect Comparative Efficacy and Safety of Tirzepatide Versus Oral Semaglutide for the Treatment of Overweight and Obesity.

Diabetes, obesity & metabolism·2026

Related Experiment Video

Updated: Mar 5, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

20.0K

Paraneoplastic endocrine syndromes.

Georgios K Dimitriadis1, Anna Angelousi2, Martin O Weickert3

  • 1The Arden NET CoEWarwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK g.dimitriadis@warwick.ac.uk.

Endocrine-Related Cancer
|March 26, 2017
PubMed
Summary
This summary is machine-generated.

Endocrine paraneoplastic syndromes are rare but significant clinical conditions where tumors secrete substances causing characteristic symptoms. Early detection aids diagnosis and monitoring, but more research is needed for effective management.

Keywords:
Cushing’s syndromeSIADHacromegalyendocrine tumourshypercalcaemiahypoglycaemiaparaneoplastic syndromes

More Related Videos

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
09:48

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology

Published on: February 25, 2022

4.7K

Related Experiment Videos

Last Updated: Mar 5, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

20.0K
Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
09:48

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology

Published on: February 25, 2022

4.7K

Area of Science:

  • Oncology
  • Endocrinology
  • Clinical Medicine

Background:

  • Neoplasms typically cause symptoms via mass effects or metastasis.
  • Occasionally, neoplasms secrete bioactive substances or induce immune responses, leading to clinical syndromes.
  • Endocrine paraneoplastic syndromes occur when secreted substances are unrelated to the tumor's tissue of origin.

Purpose of the Study:

  • To discuss the nature and clinical significance of endocrine paraneoplastic syndromes.
  • To highlight their role in diagnosis, treatment monitoring, and prognosis.
  • To emphasize the need for further research and clinical trials.

Main Methods:

  • Review of existing literature on endocrine paraneoplastic syndromes.
  • Analysis of the clinical presentation, pathogenesis, and diagnostic implications.
  • Discussion of current understanding and future research directions.

Main Results:

  • Endocrine paraneoplastic syndromes can precede, coincide with, or follow tumor development.
  • Their detection can serve as a biological 'fingerprint' for early neoplasia diagnosis and recurrence monitoring.
  • While not always impacting prognosis in low-grade tumors, they are associated with poorer survival in highly malignant cases.

Conclusions:

  • Endocrine paraneoplastic syndromes are complex manifestations of cancer with significant diagnostic and prognostic implications.
  • Improved understanding and diagnostic capabilities have emerged, yet management is often guided by limited evidence.
  • Prospective multicenter trials are crucial for establishing evidence-based diagnostic and therapeutic protocols for these rare syndromes.