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Updated: Mar 5, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

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Pathogenic variants in the healthy elderly: unique ethical and practical challenges

Paul Lacaze1, Joanne Ryan1, Robyn Woods1

  • 1Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, ASPREE - Monash University, Melbourne, Victoria, Australia.

Journal of Medical Ethics
|March 26, 2017
PubMed
Summary

Genetic research in healthy elderly individuals presents unique ethical challenges. This study explores managing and returning clinically actionable genetic variants to older adults, considering consent, disclosure, and family implications.

Keywords:
Elderly and Terminally IllGenethicsGenetic Counselling/Prenatal DiagnosisGenetic InformationGenetic Screening/Testing

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