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Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review
Till Weidner1, Tanja Illing2, Peter Elsner2
1Department of Dermatology, University Hospital Jena, Erfurter Straße 35, Jena, 07743, Germany. till.weidner@med.uni-jena.de.
American Journal of Clinical Dermatology
|March 26, 2017
Summary
Treatments for primary localized cutaneous amyloidosis (PLCA) are diverse but lack evidence. Further research, including randomized controlled trials, is needed for effective PLCA therapies.
Area of Science:
- Dermatology
- Pathology
Background:
- Primary localized cutaneous amyloidosis (PLCA) involves amyloid protein deposition in the skin.
- Subtypes include lichen, macular, and nodular amyloidosis.
Purpose of the Study:
- To review current treatment options for primary localized cutaneous amyloidosis (PLCA).
Main Methods:
- Systematic review of English and German articles from 1985 to 2016.
- Literature search conducted using the PubMed database.
Main Results:
- Treatment reports primarily consist of case studies and small series.
- Various treatments were documented, including retinoids, corticosteroids, and laser therapy.
- Clinical trials were scarce and lacked control groups.
Conclusions:
- No definitive treatment recommendations for PLCA can be made from current literature.
- High-quality, evidence-based therapies require randomized controlled trials.
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