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Bone Mass in Boys with Autism Spectrum Disorder
Chadi A Calarge1, Janet A Schlechte2
1Menninger Department of Psychiatry and Behavioral Science and Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, 1102 Bates Ave, Suite 790, Houston, TX, 77030, USA. chadi.calarge@bcm.edu.
Journal of Autism and Developmental Disorders
|March 26, 2017
Summary
Children and adolescents with autism spectrum disorder (ASD) showed lower bone density and strength, particularly at the radius. This suggests potential skeletal health concerns in this population.
Area of Science:
- Pediatric Endocrinology
- Neurodevelopmental Disorders
- Skeletal Biology
Background:
- Autism spectrum disorder (ASD) is a complex neurodevelopmental condition.
- Skeletal health in children and adolescents with ASD requires further investigation.
Purpose of the Study:
- To investigate bone mass and skeletal parameters in pediatric and adolescent males with ASD.
- To compare bone outcomes between individuals with and without ASD.
Main Methods:
- Study included males aged 5-17 years, some treated with risperidone.
- Measurements included anthropometry, dual-energy X-ray absorptiometry, and peripheral quantitative computed tomography.
- Multivariable linear regression analysis was used to compare skeletal outcomes.
Main Results:
- Individuals with ASD exhibited significantly lower trabecular bone mineral density and bone strength at the radius.
- A marginally lower total body less head bone mineral content was observed in the ASD group.
- No significant differences in bone parameters were found at the lumbar spine.
Conclusions:
- Autism spectrum disorder is associated with reduced bone mass and strength in pediatric males.
- Findings highlight the need for research into interventions to improve skeletal health in individuals with ASD.
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