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Primary cutaneous anaplastic large cell lymphoma.

Ryanne A Brown1, Sebastian Fernandez-Pol1, Jinah Kim1,2

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, California.

Journal of Cutaneous Pathology
|March 26, 2017
PubMed
Summary

Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a CD30+ skin lymphoma with a good prognosis. Accurate diagnosis of PC-ALCL requires careful clinicopathologic correlation due to potential overlaps with other skin lymphomas.

Keywords:
CD30+ lymphoproliferative disorderprimary cutaneous anaplastic large cell lymphoma

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Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a CD30+ lymphoproliferative disorder (LPD) of the skin.
  • CD30+ LPDs constitute 25%-30% of primary cutaneous lymphomas, second only to mycosis fungoides.
  • PC-ALCL generally has a favorable prognosis unless high-stage disease is present.

Purpose of the Study:

  • To highlight the diagnostic challenges in differentiating PC-ALCL from other cutaneous CD30+ LPDs.
  • To emphasize the importance of clinicopathologic correlation in diagnosing PC-ALCL.
  • To underscore the potential for morphologic, clinical, and molecular overlap with other hematolymphoid neoplasms.

Main Methods:

  • Clinicopathologic correlation
  • Morphologic analysis
  • Clinical assessment
  • Molecular studies

Main Results:

  • PC-ALCL diagnosis relies heavily on integrating clinical, morphologic, and molecular findings.
  • Differential diagnosis includes lymphomatoid papulosis and other aggressive hematolymphoid neoplasms.
  • Distinguishing PC-ALCL is crucial for appropriate management and prognosis.

Conclusions:

  • Accurate diagnosis of PC-ALCL is essential for patient management.
  • Comprehensive clinicopathologic evaluation is key to overcoming diagnostic challenges.
  • Understanding the overlap with other neoplasms aids in precise diagnosis and treatment planning.