Live cell biosensing platforms using graphene-based hybrid nanomaterials

Area of Science:

• Biomaterials Science
• Nanotechnology
• Cell Biology

Background:

• Precise detection of biomaterials in living cells is crucial for understanding cellular processes.
• Graphene and its derivatives possess unique properties (e.g., conductivity, fluorescence quenching) making them suitable for biosensing.
• Graphene-based materials are biocompatible, non-toxic, and water-soluble, facilitating live cell applications.

Purpose of the Study:

• To review the use of graphene-based hybrid constructs for live cell biosensing.
• To highlight the potential applications of these biosensors in cancer research and stem cell therapy.

Main Methods:

• Review of existing literature on graphene-based hybrid nanomaterials for biosensing.
• Analysis of studies employing graphene as a core material or in combination with other nanomaterials.
• Examination of detection capabilities for various cellular entities (ions, biomolecules, proteins, cells).

Main Results:

• Graphene-based hybrid nanomaterials effectively detect diverse cellular entities in living cells.
• These materials can be functionalized with probes, dyes, and signaling molecules for targeted detection.
• Demonstrated utility in detecting ions, biomolecules, genetic materials, proteins, enzymes, and whole cells.

Conclusions:

• Graphene-based hybrid nanomaterials represent a powerful tool for live cell biosensing.
• Their versatility supports advancements in understanding cellular mechanisms.
• Significant potential exists for applications in critical fields like cancer research and stem cell therapy.