[Therapeutic Aggressiveness and Liquid Oncology]
F J Barón Duarte1, M S Rodríguez Calvo2, J R Amor Pan3
1Servicio de Oncología Médica. Hospital Clínico Universitario de Santiago. Trv Choupana s/n. Santiago de Compostela A Coruña. Tfno. 676903416 correo: paco.baron@ telefonica.net.
Summary
Therapeutic aggressiveness in advanced cancer patients is more frequent than recommended, with about 25% meeting criteria. Improving end-of-life care requires focusing on patient dignity and communication.
Area of Science:
- Oncology
- Palliative Care
- Medical Ethics
Background:
- Established criteria for therapeutic aggressiveness exist but are not widely used in Oncology Services evaluation.
- Aggressiveness in end-of-life cancer care remains a significant concern impacting patient quality of life.
Purpose of the Study:
- To analyze the prevalence of therapeutic aggressiveness in advanced cancer patients using standard criteria.
- To evaluate end-of-life care practices in a cohort of deceased advanced cancer patients.
Main Methods:
- Retrospective analysis of 1,001 advanced cancer patients who died between 2010 and 2013.
- Application of established scientific criteria to assess therapeutic aggressiveness.
Main Results:
- Approximately 25% of patients exhibited at least one criterion of therapeutic aggressiveness.
- End-of-life aggressiveness was observed more frequently than expert recommendations suggest.
Conclusions:
- Current oncology practices may overemphasize treatment over patient-centered care, potentially neglecting the patient as a moral subject.
- Implementing Advanced Care Planning, respecting patient values, and limiting therapeutic effort can reduce aggressiveness and enhance end-of-life care.
- A shift towards dignity, communication, and patient-centeredness is crucial for improving clinical practice in advanced cancer care.
Related Concept Videos
Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
Cancer Therapies
10.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.5K
Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K


