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Updated: Mar 5, 2026
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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
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Tacrolimus-Induced Reversible Cerebral Vasoconstriction Syndrome with Delayed Multi-Segmental Vasoconstriction
Satoshi Kodama1, Tatsuo Mano1, Akihiro Masuzawa2
1Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Summary
Reversible cerebral vasoconstriction syndrome (RCVS) can be induced by tacrolimus, a medication used after heart transplants. This case highlights the need for ongoing monitoring of cerebral arteries even after initial symptom improvement.
Area of Science:
- Neurology
- Pharmacology
- Cardiology
Background:
- Reversible cerebral vasoconstriction syndrome (RCVS) is a cerebrovascular condition involving temporary narrowing of brain arteries.
- Its precise cause is unknown, but it's thought to involve vascular tone dysregulation.
Observation:
- A 15-year-old heart transplant patient developed RCVS and seizures post-surgery, linked to tacrolimus use.
- Initial MRI showed vasoconstrictions, brain edema, and subarachnoid hemorrhage.
Findings:
- Neurological symptoms improved after stopping tacrolimus.
- However, follow-up angiography revealed delayed progression of vasoconstrictions before eventual resolution.
Implications:
- Tacrolimus can induce RCVS, necessitating careful neurological monitoring in transplant patients.
- Continuous vascular imaging and vasodilator management are crucial for delayed RCVS progression, even with clinical improvement.
Keywords:
Vasoconstrictionangiographycalcineurin inhibitormagnetic resonance imagingstrokesubarachnoid hemorrhageMore Related Videos
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