Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Additional Subnuclear Structures02:10

Additional Subnuclear Structures

5.5K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
5.5K
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

2.7K
2.7K
The Nucleus01:32

The Nucleus

107.4K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
107.4K
The Nucleus01:25

The Nucleus

8.2K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
8.2K
DNA Packaging00:58

DNA Packaging

114.2K
Overview
114.2K
Nuclear Protein Sorting01:34

Nuclear Protein Sorting

6.5K
Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Omega stabilizes RNA polymerase condensates and contributes to cellular fitness during acid stress.

bioRxiv : the preprint server for biology·2026
Same author

Labeling of nascent RNA in the C. elegans intestine.

PloS one·2026
Same author

Size Matters: A Biophysical Perspective on Biomolecular Condensates in Bacteria.

Annual review of biophysics·2025
Same author

Genome integrity relies on rapid recycling of DNA Pol III in bacteria.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Resource-use plasticity governs the causal relationship between traits and community structure in model microbial communities.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Transcription-templated assembly of the nucleolus in the <i>Caenorhabditis elegans</i> embryo.

Proceedings of the National Academy of Sciences of the United States of America·2025

Related Experiment Video

Updated: Mar 5, 2026

Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays
06:33

Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays

Published on: June 28, 2024

947

Sequence-encoded material properties dictate the structure and function of nuclear bodies.

Stephanie C Weber1

  • 1Department of Biology, McGill University, Montreal, QC H3A 1B1, Canada.

Current Opinion in Cell Biology
|March 27, 2017
PubMed
Summary

The cell nucleus organizes its contents into membraneless nuclear bodies through phase separation. Recent research reveals the material properties and molecular underpinnings of these crucial structures.

More Related Videos

Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy
10:57

Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy

Published on: November 11, 2025

894
Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
16:27

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Published on: September 14, 2011

13.0K

Related Experiment Videos

Last Updated: Mar 5, 2026

Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays
06:33

Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays

Published on: June 28, 2024

947
Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy
10:57

Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy

Published on: November 11, 2025

894
Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation
16:27

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Published on: September 14, 2011

13.0K

Area of Science:

  • Cell Biology
  • Biophysics
  • Molecular Biology

Background:

  • The cell nucleus spatially organizes the nucleoplasm alongside genome packaging.
  • Nuclear bodies are phase-separated, membraneless organelles within the nucleoplasm.
  • Understanding nuclear body formation and function is critical for cell biology.

Purpose of the Study:

  • To review recent advances in understanding nuclear body material properties.
  • To highlight the molecular basis of phase-separated nuclear bodies.
  • To identify emerging challenges in the study of nuclear organization.

Main Methods:

  • Literature review of recent scientific publications.
  • Synthesis of findings on nuclear body material properties.
  • Analysis of molecular mechanisms driving phase separation.

Main Results:

  • Significant progress has been made in linking material properties to nuclear body structure and function.
  • The molecular basis for the formation of these condensed phases is becoming clearer.
  • New research directions and challenges have been identified.

Conclusions:

  • Nuclear bodies form through phase separation, with their material properties dictating function.
  • Ongoing research is elucidating the molecular players involved in nuclear body formation.
  • The field faces exciting new challenges in understanding nuclear organization and dynamics.