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Gut Microbiome in Chronic Kidney Disease.
R G Armani1, A Ramezani2, A Yasir2
1Nephrology Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Current Hypertension Reports
|March 27, 2017
Summary
Gut microbiome dysbiosis is common in chronic kidney disease (CKD), leading to harmful uremic toxins. Targeting the gut microbiome offers potential new therapies for CKD patients.
Area of Science:
- Microbiology
- Nephrology
- Gastroenterology
Background:
- The gut microbiome, comprising over 100 trillion microbial cells, is crucial for health and disease.
- Gut microbiome dysbiosis, characterized by altered composition/function and disrupted gut barrier, is prevalent in chronic kidney disease (CKD).
Purpose of the Study:
- To review the consequences of gut dysbiosis in CKD.
- To highlight recent therapeutic interventions targeting the gut microbiome for CKD management.
Main Methods:
- This is a review article, synthesizing existing research on the gut microbiome in CKD.
- Literature search and analysis of studies investigating gut dysbiosis and therapeutic strategies in CKD.
Main Results:
- Dysbiotic gut microbiomes in CKD patients produce excessive uremic toxins.
- Impaired intestinal barriers allow these toxins to enter systemic circulation, contributing to CKD progression and cardiovascular risk.
Conclusions:
- Gut dysbiosis significantly impacts CKD progression and associated cardiovascular risks.
- Therapeutic interventions aimed at restoring gut microbiome symbiosis show promise for managing CKD.
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