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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
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[Acute respiratory distress syndrome in childhood: Changing definition and news from the Pediatric Consensus

S Dauger1, F Le Bourgeois1, J Guichoux2

  • 1Service de réanimation et surveillance continue pédiatriques, pôle de pédiatrie médicale, et Inserm U1141, hôpital universitaire Robert-Debré, Assistance publique-Hôpitaux de Paris et Université Denis-Diderot, Paris VII, 48, boulevard Sérurier, 75019 Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|March 28, 2017
PubMed

Insights

Pediatric Acute Respiratory Distress Syndrome (ARDS) guidelines were established in 2015 by the Pediatric Acute Lung Injury Consensus Conference (PALICC) to address specific needs in children. These guidelines offer improved diagnosis and treatment strategies for pediatric ARDS.

Area of Science:

  • Pediatric critical care medicine
  • Respiratory medicine
  • Pulmonology

Background:

  • Acute Respiratory Distress Syndrome (ARDS) is a severe lung condition characterized by alveolar flooding and hypoxemic respiratory failure.
  • Pediatric ARDS is less common than adult ARDS, historically leading to the application of adult treatment protocols in children.
  • The evolution of ARDS definitions since 1967 highlights the need for specialized pediatric care.

Framework:

  • The Pediatric Acute Lung Injury Consensus Conference (PALICC) convened in 2015 to develop the first international guidelines specifically for pediatric ARDS.
  • These guidelines provide a structured approach to diagnosing and managing ARDS in pediatric patients.
  • The PALICC framework emphasizes a consensus-driven, evidence-based approach tailored to the unique physiology of children.

Implementation:

  • The guidelines offer practical recommendations for the diagnosis of pediatric ARDS, considering its distinct clinical presentations.
  • Therapeutic strategies outlined by PALICC focus on lung-protective ventilation, appropriate fluid management, and supportive care.
  • Implementation involves integrating these specialized guidelines into pediatric intensive care units (PICUs) worldwide.

Implications:

  • Adoption of PALICC guidelines is expected to improve outcomes for children with ARDS, reducing morbidity and mortality.
  • These guidelines facilitate standardized, high-quality care for pediatric ARDS, bridging the gap between adult and pediatric treatment approaches.
  • Future research and clinical practice will be guided by the PALICC framework, advancing the understanding and management of pediatric lung injury.

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