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Left Ventricular Non-Compaction: A Cardiomyopathy With Acceptable Prognosis in Children

Tao Tian1, Yankun Yang1, Lanlan Zhou2

  • 1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Mediacal College, Beijing 100037, China.

Heart, Lung & Circulation
|March 28, 2017
PubMed

Insights

Left ventricular non-compaction (LVNC) in children is often missed on echocardiograms. Congenital heart disease and WPW syndrome are common in pediatric LVNC cases.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Imaging
  • Congenital Heart Disease

Background:

  • Left ventricular non-compaction (LVNC) data in pediatric populations is limited.
  • Understanding clinical profiles of LVNC in Chinese children is crucial.

Purpose of the Study:

  • To evaluate the clinical characteristics of left ventricular non-compaction (LVNC) in Chinese children.
  • To assess the diagnostic challenges and associated conditions in pediatric LVNC.

Main Methods:

  • Prospective recruitment of Chinese children (<18 years) diagnosed with LVNC via cardiovascular magnetic resonance (CMR).
  • Study period: January 2010 to March 2016 at Fuwai Hospital.
  • Inclusion criteria: LVNC diagnosis by CMR.

Main Results:

  • 41 children with LVNC were studied; 32% were initially missed by echocardiography.
  • Associated conditions included congenital heart disease (27%) and Wolff-Parkinson-White (WPW) syndrome (10%).
  • Lower LVEF and blood pressure predicted poorer outcomes, with advanced heart failure and LGE indicating worse prognosis.

Conclusions:

  • LVNC can be overlooked during echocardiographic evaluation.
  • Congenital heart disease and WPW syndrome are relatively frequent comorbidities in pediatric LVNC.
  • The prognosis for children with LVNC may be more favorable than previously reported, warranting further long-term investigation.
Abstract

Keywords:
ChildrenChinese childrenClinical presentationLeft ventricular non-compactionPrognosis

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