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13:04
A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
American Gastroenterological Association Institute Clinical Practice Update-Expert Review: Care of Patients Who Have
Ira M Jacobson1, Joseph K Lim2, Michael W Fried3
1Department of Medicine, Mount Sinai Beth Israel Medical Center, Icahn School of Medicine at Mount Sinai, New York, New York.
Gastroenterology
|March 28, 2017
Summary
Hepatitis C virus (HCV) cure is achievable with direct-acting antivirals, but some patients need ongoing monitoring for liver cancer and cirrhosis risks. This update provides guidance for managing patients after successful HCV treatment.
Area of Science:
- Hepatology
- Infectious Diseases
- Public Health
Background:
- Chronic hepatitis C virus (HCV) infection impacts millions globally, leading to liver cirrhosis and cancer.
- Direct-acting antiviral (DAA) therapies achieve high sustained virologic response (SVR) rates, generally over 90%.
Purpose of the Study:
- To provide clinical practice recommendations for the post-SVR care of patients with chronic HCV.
- To address the limited evidence guiding monitoring strategies for patients who achieved SVR.
Main Methods:
- Review of available evidence.
- Incorporation of expert opinion.
- Development of best practice recommendations.
Main Results:
- SVR significantly reduces risks of liver cirrhosis, decompensation, and mortality.
- A subset of patients remain at long-term risk for liver disease progression and hepatocellular carcinoma post-SVR.
Conclusions:
- Post-SVR monitoring is crucial for a subset of patients to manage long-term risks.
- Evidence-based guidelines are needed to direct the intensity and duration of monitoring for these patients.
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