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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Core/shell poly(ethylene oxide)/Eudragit fibers for site-specific release.

Dong Jia1, Yanshan Gao1, Gareth R Williams1

  • 1UCL School of Pharmacy, University College London, London WC1N 1AX, UK.

International Journal of Pharmaceutics
|March 28, 2017
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Core/shell electrospun fibers loaded with indomethacin or mebeverine hydrochloride offer controlled drug release. These mucoadhesive fibers prevent premature drug release in the stomach and provide sustained intestinal delivery, showing promise for treating inflammatory bowel disease and colon cancer.

Keywords:
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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biomedical Engineering

Background:

  • Core/shell electrospun fibers offer advanced drug delivery systems.
  • Mucoadhesive polymers enhance localized drug retention in the gastrointestinal tract.
  • pH-sensitive polymers enable targeted drug release in specific intestinal regions.

Purpose of the Study:

  • To develop and characterize core/shell electrospun fibers for controlled release of indomethacin and mebeverine hydrochloride.
  • To evaluate the mucoadhesive properties and drug release profiles of the fabricated fibers.
  • To assess the potential of these fibers for treating gastrointestinal conditions like irritable bowel disease and colon cancer.

Main Methods:

  • Core/shell fibers were fabricated using electrospinning with Eudragit S100 (shell) and poly(ethylene oxide) (PEO) (core).
  • Active pharmaceutical ingredients (indomethacin or mebeverine hydrochloride) were incorporated into the PEO core at varying drug loadings.
  • Fiber morphology was analyzed using transmission electron microscopy, and drug release was assessed through dissolution tests at different pH levels.

Main Results:

  • Electrospun fibers exhibited distinct core/shell structures with drugs in amorphous form.
  • Fibers effectively prevented drug release in acidic (stomach) conditions and demonstrated sustained release (6-22 hours) at pH 7.4.
  • Mucoadhesive PEO core facilitated fiber adhesion to intestinal walls post-shell dissolution.

Conclusions:

  • The developed core/shell electrospun fibers provide a promising platform for localized and sustained drug delivery in the gastrointestinal tract.
  • The mucoadhesive and pH-responsive properties enable targeted release, potentially improving therapeutic outcomes for conditions like irritable bowel disease and colon cancer.
  • This technology offers a novel approach to enhance the efficacy of existing drugs through advanced drug delivery system design.