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Receptor-Mediated Drug Delivery Systems Targeting to Glioma

Shanshan Wang1, Ying Meng2, Chengyi Li3

  • 1Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China. 14211030067@fudan.edu.cn.

Nanomaterials (Basel, Switzerland)
|March 28, 2017
PubMed

Insights

Receptor-mediated drug delivery offers a promising strategy to target glioma, a common brain tumor. This approach enhances drug delivery to tumors while minimizing side effects, improving patient outcomes.

Area of Science:

  • Neuro-oncology
  • Nanomedicine
  • Pharmacology

Background:

  • Glioma is the most common primary central nervous system (CNS) tumor.
  • Standard treatments (surgery, radiotherapy, chemotherapy) show limited efficacy due to glioma complexity and the blood-brain barrier (BBB).
  • Novel therapeutic strategies are crucial for improving glioma patient survival and prognosis.

Purpose of the Study:

  • To review recent advancements in receptor-mediated drug delivery systems for targeted glioma therapy.
  • To highlight the potential of exploiting differential receptor expression for active drug transport.
  • To discuss challenges and future prospects of this targeted therapeutic approach.

Main Methods:

  • Review of current literature on receptor-mediated drug delivery systems.
  • Analysis of strategies utilizing receptor expression differences between glioma and normal tissues.
  • Examination of drug delivery vehicles (small molecules, gene medicines, proteins) for glioma targeting.

Main Results:

  • Receptor-mediated drug delivery actively transports therapeutic agents to glioma.
  • This strategy minimizes systemic adverse reactions by targeting tumor-specific receptors.
  • Successful examples of receptor-mediated systems demonstrate improved drug accumulation in glioma models.

Conclusions:

  • Receptor-mediated drug delivery presents a viable strategy to overcome BBB limitations and enhance glioma treatment.
  • Targeted delivery improves therapeutic efficacy and reduces toxicity compared to conventional methods.
  • Further research into receptor-mediated systems holds significant promise for future glioma therapy.
Keywords:
blood-brain barrier (BBB)dual ligand-modified targeting systemsgliomareceptor-mediatedsingle ligand-modified targeting systems

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