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Age-associated decrease in beta-adrenergic receptors and adenylate cyclase activity in rat brown adipose tissue.

P J Scarpace1, A D Mooradian, J E Morley

  • 1Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Sepulveda.

Journal of Gerontology
|May 1, 1988
PubMed
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Aging impairs body temperature regulation in rats. Brown adipose tissue (BAT) shows reduced beta-adrenergic receptors and adenylate cyclase activity, contributing to thermoregulatory decline in older animals.

Area of Science:

  • Aging and Thermoregulation
  • Brown Adipose Tissue (BAT) Physiology
  • Adrenergic Receptor Signaling

Background:

  • Thermoregulation effectiveness decreases with advanced age.
  • Brown adipose tissue (BAT) is crucial for nonshivering thermogenesis, regulated by beta-adrenergic receptor signaling.
  • Age-related decline in beta-adrenergic responsiveness impacts thermoregulation.

Purpose of the Study:

  • To investigate age-related changes in beta-adrenergic function within rat brown adipose tissue (BAT).
  • To assess alterations in beta-adrenergic receptor density and adenylate cyclase activity in aging rats.

Main Methods:

  • Assessed beta-adrenergic receptor number and cytochrome c oxidase activity in rats aged 3, 12, and 24 months.
  • Measured adenylate cyclase activity in rats aged 3, 12, 18, and 24 months.

Related Experiment Videos

  • Quantified BAT mass and enzyme activities in different age groups.

    • Main Results:

    • Senescent rats (24 months) had 30% less BAT mass and reduced total cytochrome c oxidase activity compared to younger rats.
    • Beta-adrenergic receptor density in senescent rats was half that of 3- and 12-month-old rats, primarily due to a decrease in beta 1-adrenergic receptors.
    • Adenylate cyclase activity (stimulated by isoproterenol, NaF, and forskolin) was significantly lower in older rats compared to 3-month-old rats.

    Conclusions:

    • Age-related biochemical changes in BAT, including reduced beta-adrenergic receptor density and impaired adenylate cyclase function, likely contribute to the diminished thermoregulatory capacity in older rats.
    • These findings highlight the molecular mechanisms underlying age-associated thermoregulatory deficits.