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Published on: February 26, 2013
Insomnia and the Risk of Atrial Fibrillation: A Population-Based Cohort Study
Hsiu-Hao Lee1, Yueh-Chung Chen2, Jien-Jiun Chen3
1Institution of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health; ; Department of Internal Medicine, Taipei City Hospital, Zhongxing Branch.
Background:
Although advancements in the treatment of atrial fibrillation have improved patient prognosis for this persistent condition, interest in atrial fibrillation development is growing. Of note is the fact that additional attention is being focused on the accompanying effect of insomnia. The aim of the study was to investigate the effects of insomnia on the risk of atrial fibrillation development.
Methods:
This was a nationwide population-based retrospective cohort study using data from the Taiwan National health Insurance Research Database. We analyzed 64,421 insomnia cases and 128,842 matched controls without insomnia from January 1, 2000, to December 31, 2010. A Cox regression model was used to estimate the adjusted hazard ratios (HRs) and 95% confidence intervals (CI) for atrial fibrillation development.
Results:
During the follow-up period, the incidence of atrial fibrillation development was significantly higher in the insomnia cases than in the comparison cohort (2.6% vs. 2.3%, p < 0.001). Insomnia was associated with an increased risk of atrial fibrillation (HR = 1.08, 95% CI: 1.01-1.14). Males, those > 65 years of age, and patients with peripheral artery disease who have insomnia had a higher rate of atrial fibrillation development.
Conclusions:
The findings of this nationwide analysis support the hypothesis that insomnia is associated with a significant risk of atrial fibrillation development.
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