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Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy

Eric Lazear1, Reza Ghasemi2, Sarah M Hein3

  • 1Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, NC, USA.

Oncoimmunology
|March 28, 2017
PubMed

The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and an IL-2 mutant that avoids off-target side effects such as activation of regulatory T cells and vascular endothelium.

Keywords:
CytokineInterleukin-2 (IL-2)NKG2Dcytotoxic lymphocytesimmunotargetingimmunotherapynatural killer cell (NK)

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