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CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy
Nan Chen1, Aurore Morello1, Zachary Tano2
1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Oncoimmunology
|March 28, 2017
Abstract:
PD-L1/2 expression in solid tumors inhibits chimeric antigen receptor (CAR) T-cell efficacy. A PD-1 dominant negative receptor expressed in CAR T cells provides cell-intrinsic checkpoint blockade and augments antitumor efficacy. A combinatorial immunotherapeutic strategy of combining CAR T cells with checkpoint blockade is a promising treatment approach for solid tumors.
Keywords:
Adoptive T-cell therapyPD-1 blockadebreast cancerimmunosuppressionlung cancermesotheliomatumor microenvironment
