VISUAL OUTCOME WITH A MULTIMODALITY APPROACH IN A CASE OF RHINOORBITO- CEREBRAL MUCORMYCOSIS.

Area of Science:

• Ophthalmology
• Infectious Diseases
• Mycology

Background:

• Rhino-orbito-cerebral mucormycosis is a rare, aggressive fungal infection with high mortality.
• Uncontrolled diabetes mellitus is a primary risk factor, complicating patient management.

Observation:

• A 57-year-old male presented with proptosis and ophthalmoplegia, diagnosed with rhino-orbito-cerebral mucormycosis.
• Initial treatment with intravenous amphotericin B caused systemic toxicity.

Findings:

• A multi-modality approach combining oral posaconazole and peribulbar amphotericin B was initiated.
• The patient experienced significant vision improvement and partial recovery of extraocular movements within 20 days.

Implications:

• Prompt, multi-modal management can avert the need for orbital exenteration in severe cases.
• This approach offers a promising alternative for managing rhino-orbito-cerebral mucormycosis, especially in patients with treatment-limiting toxicities.