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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.2K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.2K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.2K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

675
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
675
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

688
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

439
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
439
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

778
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
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Related Experiment Video

Updated: Mar 5, 2026

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
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Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

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Circular RNAs in heart failure.

Yvan Devaux1, Esther E Creemers2, Reinier A Boon3,4

  • 1Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg.

European Journal of Heart Failure
|March 28, 2017
PubMed
Summary
This summary is machine-generated.

Circular RNAs (ribonucleic acids) show promise as novel biomarkers and therapeutic targets for heart failure. Research highlights their unique features and potential in personalized cardiovascular care.

Keywords:
BiomarkersCircular RNAsHeart failureNon-coding RNAsTherapeutic targetsTranscriptomics

Related Experiment Videos

Last Updated: Mar 5, 2026

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
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Published on: August 30, 2024

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiovascular Medicine

Background:

  • Heart failure remains a significant global health challenge requiring innovative treatments and diagnostic tools.
  • MicroRNAs and long non-coding RNAs have emerged as important players in personalized heart failure care.
  • Circular RNAs, a less-explored RNA subgroup, present a novel avenue for heart failure research.

Purpose of the Study:

  • To review recent findings on circular RNAs in the context of heart failure.
  • To explore the biogenesis, features, and functions of circular RNAs in cardiac health and disease.
  • To discuss the potential of circular RNAs as biomarkers and therapeutic targets for heart failure.

Main Methods:

  • Literature review of recent studies on circular RNAs and heart failure.
  • Analysis of circular RNA biogenesis and functional characteristics.
  • Discussion of current research on circulating circular RNAs as heart failure biomarkers.

Main Results:

  • Circular RNAs possess unique features making them relevant to heart failure research.
  • Their expression and regulation are altered in the failing heart.
  • Circulating circular RNAs demonstrate potential as non-invasive biomarkers for heart failure.

Conclusions:

  • Circular RNAs represent a promising, novel class of molecules for heart failure diagnostics and therapeutics.
  • Further research into their biogenesis, function, and clinical utility is warranted.
  • Circular RNAs could significantly advance personalized medicine approaches for heart failure patients.