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VEGFR-3 Expression in Oral Lichen Planus
Zahra Zolfaghari Saravi1, Maryam Seyedmajidi, Majid Sharbatdaran
1Oral and Maxillofacial Pathology Department, Dental Faculty, Babol University of Medical Sciences, Babol, Iran.
Asian Pacific Journal of Cancer Prevention : APJCP
|March 28, 2017
Summary
Vascular Endothelial Growth Factor Receptor 3 (VEGFR-3) is significantly present in oral lichen planus, suggesting its role in the disease's pathogenesis via increased lymphangiogenesis.
Area of Science:
- Oral pathology
- Immunohistochemistry
- Molecular biology
Background:
- Oral lichen planus (OLP) is associated with inflammation and potential lymphangiogenesis.
- Vascular Endothelial Growth Factor Receptor 3 (VEGFR-3) is a key mediator of lymphangiogenesis.
Purpose of the Study:
- To investigate the presence and significance of VEGFR-3 in oral lichen planus.
- To explore the potential role of VEGFR-3 in the pathogenesis of OLP.
Main Methods:
- A cross-sectional study involving 52 OLP tissue samples and 60 normal oral mucosa samples.
- Immunohistochemical staining for VEGFR-3.
- Statistical analysis using Chi-square, Mann-Whitney, and Kruskal-wallis tests.
Main Results:
- VEGFR-3 expression was observed in 61.5% of OLP specimens compared to 5% in normal mucosa (p<0.001).
- The average number of VEGFR-3 stained vessels was significantly higher in OLP than in normal mucosa (p<0.001).
- No significant difference in VEGFR-3 expression or stained vessels was found between erosive and reticular OLP types.
Conclusions:
- VEGFR-3 expression is significantly elevated in oral lichen planus.
- Increased VEGFR-3 may contribute to the pathogenesis of OLP by promoting lymphatic vessel formation and lymphangiogenesis.
