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Updated: Mar 5, 2026

In vivo Interrogation of Central Nervous System Translatome by Polyribosome Fractionation
Published on: April 30, 2014
Collaterals 2016: Translating the collaterome around the globe.
David S Liebeskind1, Graham W Woolf1, Ashfaq Shuaib2
11 Neurovascular Imaging Research Core and UCLA Stroke Center, University of California, Los Angeles, CA, USA.
The Collaterals 2016 symposium addressed critical challenges in acute ischemic stroke treatment, focusing on collateral circulation and the collaterome for precision medicine. The event fostered global collaboration and knowledge sharing on optimizing stroke therapy through enhanced collateral assessment.
Area of Science:
- Neurology
- Vascular Medicine
- Medical Conferences
Background:
- Acute ischemic stroke treatment faces challenges in selecting patients for definitive therapy based on collateral status.
- Understanding the individual's collaterome (capacity to offset ischemia) is crucial for precision stroke medicine.
- Disseminating expert methods and leveraging networking are vital for advancing stroke science.
Purpose of the Study:
- To convene global experts to discuss collateral circulation in acute ischemic stroke.
- To address challenges in applying collateral status for optimal patient triage and treatment selection.
- To foster networking and rapid dissemination of knowledge on the collaterome and stroke therapy.
Main Methods:
- A multidisciplinary scientific conference (Collaterals 2016) was held, convening over 50 international faculty.
- The program included sessions focused on translating the collaterome concept into acute stroke therapy.
- A hybrid format connected on-site and remote participants from over 22 countries, utilizing innovative videoconferencing.
Main Results:
- The conference facilitated discussion on pivotal factors in precision stroke medicine, including the collaterome and collateral profiles.
- It highlighted the need for generalizable triage paradigms based on collateral status for acute ischemic stroke.
- The event successfully connected global experts, promoting networking and knowledge diffusion.
Conclusions:
- Collateral status and the collaterome are key considerations for precision medicine in acute ischemic stroke.
- The symposium provided a valuable platform for global collaboration and advancing the understanding of collateral circulation.
- The meeting format serves as a model for future international scientific conferences in stroke science.
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