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Relationship between Hepatitis C Virus Infection and Iron Overload

Dong-Mei Zou1, Wan-Ling Sun1

  • 1Department of Hematology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Chinese Medical Journal
|March 28, 2017
PubMed

Insights

Chronic hepatitis C (CHC) causes iron overload by decreasing hepcidin levels. Iron influences the hepatitis C virus (HCV) life cycle, particularly its translation.

Area of Science:

  • Hepatology
  • Virology
  • Iron Metabolism

Background:

  • Chronic hepatitis C (CHC) is frequently associated with iron overload.
  • The interplay between iron metabolism and hepatitis C virus (HCV) infection is complex and not fully understood.

Purpose of the Study:

  • To review the interactions between HCV infection and iron overload.
  • To elucidate the mechanisms of iron overload in CHC.
  • To understand iron's role in the HCV life cycle.

Main Methods:

  • Literature review of PubMed articles up to January 28, 2017.
  • Keywords included: "hepatitis C virus", "iron overload", "iron metabolism", "hepcidin", "translation", and "replication".

Main Results:

  • HCV infection leads to iron overload through decreased hepcidin levels via specific signaling pathways (STAT3, MAPK, BMP/SMAD).
  • Iron's effect on HCV replication is debated, with conflicting findings in studies.
  • Most evidence suggests iron positively impacts HCV translation by upregulating factors like eIF3 and La protein.

Conclusions:

  • CHC contributes to iron overload, which in turn influences the HCV life cycle.
  • Further research is needed to fully clarify the intricate mechanisms governing the iron-HCV interaction.
Abstract

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