Related Experiment Video
Updated: Mar 5, 2026

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
Published on: September 16, 2025
Effects of Myopic Orthokeratology on Visual Performance and Optical Quality
Guihua Liu1, Zhi Chen, Feng Xue
1Tianjin Medical University Eye Hospital (G.L., J.L., R.W.), Tianjin Medical University Eye Institute and Tianjin Medical University School of Optometry and Ophthalmology, Tianjin, China; Department of Cornea and Refractive Surgery (G.L., J.L., R.W.), Tianjin Medical University Eye Hospital, Tianjin, China; Department of Ophthalmology and Vision Science (Z.C., F.X., M.T., X.Z.), EYE and ENT Hospital of Fudan University, Shanghai, China; and Key Lab of Myopia (Z.C., F.X., M.T., X.Z.), Ministry of Health, Shanghai, China.
Objectives:
To analyze the changes in visual performance and optical quality after orthokeratology (ortho-k) treatment and its correlation with the magnitude of lens decentration and the diameter of treatment zone (TxZ).
Methods:
A prospective study was conducted in 27 eyes of 27 patients wearing ortho-k contact lens. Area under log contrast sensitivity function (AULCSF), modulation transfer function cutoff values (MTFcutoff), Strehl ratio (SR), and objective scattering index (OSI) were measured and compared before and 1 month after ortho-k lens treatment. Refractive sphere, astigmatism, and diameter and decentration of TxZ were tested against the change in AULCSF, MTFcutoff, SR, and OSI after ortho-k treatment in stepwise multiple linear regression models.
Results:
Objective scattering index significantly increased and AULCSF, MTFcutoff, and SR significantly decreased after ortho-k lens wear (all P<0.001). The mean TxZ diameter was 3.61±0.26 mm, and the mean magnitude of TxZ decentration was 0.60±0.16 mm. The amount of lens decentration significantly correlated with the change in AULCSF and MTFcutoff (P=0.027 and P=0.005, respectively). The diameter of TxZ significantly correlated with the change in MTFcutoff and SR (P=0.005 and P=0.024, respectively).
Conclusions:
Visual and optical quality decreases after ortho-k treatment, which can be alleviated by a larger TxZ diameter and a smaller lens decentration.
Related Concept Videos
Focusing of Light in the Eye
Photoreceptors and Visual Pathways
Accessory Structures of the Eye
Angle Closure Glaucoma: Treatment
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview

