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Published on: December 8, 2023
New Acorane-Type Sesquiterpene from Acorus calamus L
Juan Li1, Jianping Zhao2, Wei Wang3
1Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China. forever_lijuan@163.com.
Abstract:
A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 are nonisoprenoid sesquiterpenoids, likely biosynthesized from an acorane-type sesquiterpene by oxidative fission of the six- or five-membered ring. Moreover, compounds 1 (10 μM), 2 (5 μM and 10 μM) and 3 (10 μM) showed cell proliferation activity on the SK-N-BE (2) cell line.
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