Related Experiment Video
Updated: Mar 5, 2026

Spin Saturation Transfer Difference NMR SSTD NMR: A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes
Published on: November 12, 2016
Proton Exchange in a Paramagnetic Chemical Exchange Saturation Transfer Agent from Experimental Studies and ab Initio
Rodolphe Pollet1, Célia S Bonnet2, Pascal Retailleau3
1NIMBE, CEA, CNRS, Université Paris-Saclay, CEA Saclay , 91191 Gif-sur-Yvette Cedex, France.
Abstract:
The proton-exchange process between water and a carbamate has been studied experimentally and theoretically in a lanthanide-based paramagnetic chemical exchange saturation transfer agent endowed with potential multimodality detection capabilities (optical imaging, or T1 MRI for the Gd(III) analogue). In addition to an in-depth structural analysis by a combined approach (using X-ray crystallography, NMR, and molecular dynamics), our ab initio simulation in aqueous solution sheds light on the reaction mechanism for this proton exchange, which involves structural Grotthuss diffusion.
More Related Videos
Related Concept Videos
Double Resonance Techniques: Overview
Spin decoupling is usually achieved by...
Proton (¹H) NMR: Chemical Shift
Absorption signals of all the protium nuclei...
π Electron Effects on Chemical Shift: Aromatic and Antiaromatic Compounds
NMR Spectroscopy: Spin–Spin Coupling
π Electron Effects on Chemical Shift: Overview
Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

