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Imaging Biological Samples with Optical Microscopy01:18

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Upconverting NIR Photons for Bioimaging.

Zhanjun Li1, Yuanwei Zhang2, Hieu La3

  • 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. zhanjun.li@umassmed.edu.

Nanomaterials (Basel, Switzerland)
|March 29, 2017
PubMed
Summary
This summary is machine-generated.

Lanthanide-doped upconverting nanoparticles (UCNPs) convert near-infrared light into higher energy emissions for advanced bioimaging and therapeutics. Their tunable properties enable deep-tissue applications, driving progress in material design and theranostics.

Keywords:
optical imagingoptical therapyupconversion nanoparticles

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Lanthanide-doped upconverting nanoparticles (UCNPs) exhibit unique anti-Stokes optical properties, converting low-energy near-infrared (NIR) photons into higher-energy UV, visible, or shorter NIR emissions through multiphoton upconversion.
  • Advances in synthesis chemistry allow for the fabrication of UCNPs with narrow size distribution and tunable multi-color optical properties.

Purpose of the Study:

  • To review the fundamental concepts and recent advancements in lanthanide-doped UCNPs.
  • To highlight progress in material engineering and theranostic applications of UCNPs, including bioimaging, molecular delivery, and tumor therapeutics.
  • To discuss the typical progress in basic mechanisms and material design for UCNP-based bioimaging tools.

Main Methods:

  • Review of scientific literature on lanthanide-doped upconverting nanoparticles.
  • Analysis of material engineering techniques for UCNP synthesis and property tuning.
  • Examination of theranostic applications, focusing on bioimaging, drug delivery, and cancer therapy.

Main Results:

  • UCNPs offer unique NIR-driven capabilities for deep-tissue imaging and therapeutic applications.
  • Tunable optical properties and controlled synthesis enable multi-color emission and targeted functionalities.
  • Significant progress has been made in leveraging UCNPs for advanced bioimaging and theranostic strategies.

Conclusions:

  • Lanthanide-doped UCNPs are promising nanomaterials with significant potential in biomedical fields.
  • Continued research in material design and understanding of upconversion mechanisms will further enhance their theranostic capabilities.
  • UCNPs are poised to play a crucial role in the development of next-generation bioimaging tools and cancer therapeutics.