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Updated: Mar 5, 2026

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion
Published on: May 4, 2011
Importance of amygdala noradrenergic activity and large-scale neural networks in regulating emotional arousal effects
Benno Roozendaal1, Laura Luyten1, Lycia D de Voogd1
1Department of Cognitive Neuroscience,Radboud University Medical Center,6500 HB Nijmegen,The Netherlandsbenno.roozendaal@radboudumc.nl.
Abstract:
Mather and colleagues postulate that norepinephrine promotes selective processing of emotionally salient information through local "hotspots" where norepinephrine release interacts with glutamatergic activity. However, findings in rodents and humans indicate that norepinephrine is ineffective in modulating mnemonic processes in the absence of a functional amygdala. We therefore argue that emphasis should shift toward modulatory effects of amygdala-driven changes at the network level.
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