Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transport pathways in rat lingual epithelium.

S A Simon1, R Robb, S S Schiffman

  • 1Department of Physiology, Duke University Medical Center, Durham, NC 27710.

Pharmacology, Biochemistry, and Behavior
|February 1, 1988
PubMed
Summary

Ion transport in rat tongues was measured and linked to nerve signals. Sodium and potassium ion pathways were identified, explaining taste responses to salt and supporting the use of lingual epithelium for taste research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-nutritive sweeteners in breast milk: perspective on potential implications of recent findings.

Archives of toxicology·2015
Same author

Multisensory Processing of Gustatory Stimuli.

Chemosensory perception·2015
Same author

Gustatory and reward brain circuits in the control of food intake.

Advances and technical standards in neurosurgery·2011
Same author

Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels.

British journal of pharmacology·2009
Same author

The gustatory cortex and multisensory integration.

International journal of obesity (2005)·2009
Same author

Evaluation of human fibroblast growth factor 23 (FGF-23) C-terminal and intact enzyme-linked immunosorbent-assays in end-stage renal disease patients.

Clinical laboratory·2009

Area of Science:

  • Physiology
  • Neuroscience
  • Sensory Biology

Background:

  • Taste perception involves complex ion transport mechanisms.
  • Electrophysiological recordings from taste nerves provide insights into sensory processing.

Purpose of the Study:

  • To correlate ion transport in isolated rat lingual epithelium with electrophysiological recordings from taste nerves.
  • To elucidate the specific ion pathways involved in taste transduction.

Main Methods:

  • Isolated rat lingual epithelium ion transport measurements.
  • Electrophysiological recordings from chorda tympani nerve bundle (CT) and nucleus of the solitary tract (NST).
  • Pharmacological inhibition of ion channels (amiloride, 4-aminopyridine, BaCl2).

Related Experiment Videos

Main Results:

  • Sodium ions cross the lingual epithelium via an amiloride-inhibitable pathway and Na+-K+-ATPase.
  • Potassium ions utilize specific pathways, inhibited by 4-aminopyridine and BaCl2.
  • NaCl elicited stronger responses than KCl in both epithelial and neural measurements.
  • Epithelial responses to hyposmotic NaCl included inward sodium and outward chloride currents.
  • D-glucose and sucrose showed minimal stimulation.

Conclusions:

  • Ion transport mechanisms in the lingual epithelium partially explain taste nerve responses.
  • Amiloride and 4-aminopyridine effects on ion transport align with electrophysiological data.
  • Isolated lingual epithelium is a viable model for studying taste transduction.