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Updated: Mar 5, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
Published on: November 21, 2025
Multimodal analgesia and regional anaesthesia
C Tornero Tornero1, L E Fernández Rodríguez2, J Orduña Valls3
1Unidad del Dolor, Servicio de Anestesiología, Hospital Clínico Universitario de Valencia, Valencia, España; Departamento de Anatomía Humana, Universitat de Valencia, Valencia, España.
Abstract:
Multimodal analgesia provides quality analgesia, with fewer side effects due to the use of combined analgesics or analgesic techniques. Regional anaesthesia plays a fundamental role in achieving this goal. The different techniques of regional anaesthesia that include both peripheral and central blocks in either a single dose or in continuous infusion help to modulate the nociceptive stimuli that access the central level. The emergence of the ultrasound as an effective system to perform regional anaesthesia techniques has allowed the development of new regional anaesthesia techniques that formerly could not be carried out since only neurostimulation or skin references were used. It is essential to take into account that even with effective blocking it is advisable to associate other drugs by other routes, in this way we will be able to reduce the required doses individually and attempt to achieve a synergistic, not purely additive, effect.
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