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Cellular systems for epithelial invagination.

Esther J Pearl1, Jingjing Li1, Jeremy B A Green2

  • 1Department of Craniofacial Development and Stem Cell Biology, King's College London, London SE1 9RT, UK.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|March 29, 2017
PubMed
Summary
This summary is machine-generated.

Epithelial invagination, a key developmental process, shapes organisms by altering cell properties. This review overviews diverse cellular mechanisms driving epithelial bending during morphogenesis.

Keywords:
apical constrictionbasal relaxationbasal wedgingcellular tractoringepithelial bendingsuprabasal intercalation

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Morphogenesis

Background:

  • Epithelial invagination is crucial for generating organismal architecture.
  • It underlies processes from gastrulation to organogenesis, including eye and ear formation.
  • This process involves coordinated cellular behaviors to achieve epithelial bending.

Purpose of the Study:

  • To provide an overview of epithelial invagination mechanisms.
  • To discuss how different mechanisms are employed in various developmental contexts.
  • To highlight the combinatorial nature of these cellular systems.

Main Methods:

  • Literature review of developmental biology studies.
  • Analysis of documented mechanisms of epithelial bending.
  • Synthesis of information on the application of these mechanisms.

Main Results:

  • Identified diverse mechanisms driving epithelial invagination.
  • Described the specific developmental circumstances for each mechanism.
  • Highlighted that multiple mechanisms can operate concurrently.

Conclusions:

  • Epithelial invagination is a versatile morphogenetic process.
  • Understanding its mechanisms is key to developmental biology.
  • The interplay of cellular systems dictates tissue formation.