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HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes
J D Rosenblatt1, A J Cann, D J Slamon
1Department of Medicine, UCLA School of Medicine.
Science (New York, N.Y.)
|May 13, 1988
Abstract:
The human T-cell leukemia virus (HTLV) types I and II have two nonstructural genes that are encoded in overlapping reading frames. One of these genes, known as tax, has been shown to encode a protein responsible for enhanced transcription (transactivation) from the viral long terminal repeats (LTRs). Genetic evidence indicates that the second nonstructural gene of HTLV-II, here designated rex, acts in trans to modulate tax gene-mediated transactivation in a concentration-dependent fashion. The rex gene may regulate the process of transactivation during the viral life cycle.