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Immunogold Electron Microscopy01:20

Immunogold Electron Microscopy

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Immunoelectron microscopy utilizes immunogold labeling of endogenous proteins with specific antibodies to detect and localize these proteins in cells and tissues. The procedure provides insights into the distribution and quantification of protein under different stimulation conditions offering clues about their functions. Conjugating highly electron-dense gold particles with primary or secondary antibodies allow antigen detection on and within cells, with high resolution and specificity.
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Related Experiment Video

Updated: Mar 5, 2026

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
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Functionalized Gold Nanoparticles and Their Biomedical Applications.

Pooja M Tiwari1, Komal Vig2, Vida A Dennis3

  • 1Center for NanoBiotechnology Research, Alabama State University, 1627, Hall Street, Montgomery, AL 36101, USA. poojatiwari@myasu.alasu.edu.

Nanomaterials (Basel, Switzerland)
|March 29, 2017
PubMed
Summary
This summary is machine-generated.

Gold nanoparticles (GNPs) offer versatile biomedical applications due to their unique properties. Functionalization enhances their targeted delivery for advanced diagnostics and therapeutics in medicine and biology.

Keywords:
bioimagingbiosensordrug deliveryfunctionalizationgene deliverygold nanoparticles

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Area of Science:

  • Nanotechnology and Materials Science
  • Biomedical Engineering
  • Pharmacology and Drug Delivery

Background:

  • Metal nanoparticles are increasingly utilized in biomedicine owing to their high surface area-to-volume ratio and thermal stability.
  • Gold nanoparticles (GNPs) are particularly favored for their facile synthesis, functionalization, low toxicity, and detectability.

Purpose of the Study:

  • To review diverse functionalization techniques for gold nanoparticles.
  • To explore the expanding biomedical applications of functionalized GNPs.
  • To highlight recent advancements in GNP functionalization for medical and biological research.

Main Methods:

  • Review of literature on gold nanoparticle synthesis and functionalization strategies.
  • Analysis of studies demonstrating GNP applications in targeted delivery, bioimaging, and therapeutics.
  • Synthesis of recent findings on GNP functionalization for medical and biological purposes.

Main Results:

  • Functionalization of GNPs enables targeted delivery to specific cell types.
  • Functionalized GNPs show significant potential in bioimaging, gene delivery, and drug delivery systems.
  • Recent advances underscore the versatility of GNPs in therapeutic and diagnostic applications.

Conclusions:

  • Functionalization is key to unlocking the full potential of gold nanoparticles in biomedical fields.
  • GNPs represent a promising platform for developing next-generation medical and biological tools.
  • Continued research in GNP functionalization will drive innovation in targeted therapies and diagnostics.