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Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
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Pentameric ligand-gated ion channels exhibit distinct transmembrane domain archetypes for folding/expression and

J P Daniel Therien1, John E Baenziger2

  • 1Department of Biochemistry, Microbiology, and Immunology University of Ottawa, Ottawa, ON, K1H 8M5, Canada.

Scientific Reports
|March 29, 2017
PubMed
Summary

Pentameric ligand-gated ion channel M4 helix interactions are crucial for folding and function. GLIC and ELIC channels show distinct archetypes, with GLIC requiring strong aromatic contacts and ELIC benefiting from weaker ones for conformational flexibility.

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